PTEN Loss Linked to Colorectal Cancer Spread and Survival
Author Information
Author(s): Sawai Hirozumi, Yasuda Akira, Ochi Nobuo, Ma Jiachi, Matsuo Yoichi, Wakasugi Takehiro, Takahashi Hiroki, Funahashi Hitoshi, Sato Mikinori, Takeyama Hiromitsu
Primary Institution: Nagoya City University Graduate School of Medical Sciences
Hypothesis
Is there a correlation between PTEN expression and the characteristics of colorectal cancer patients with and without liver metastases?
Conclusion
Loss of PTEN expression is associated with more aggressive colorectal cancer and poorer survival rates.
Supporting Evidence
- PTEN was strongly expressed in 62.9% of colorectal cancer specimens from patients without liver metastases.
- Weak PTEN expression was found in 75.4% of specimens from patients with liver metastases.
- Weak PTEN expression was significantly associated with advanced TNM stage and lymph node metastasis.
- The 5-year survival rate was significantly higher in patients with positive PTEN expression compared to those with negative PTEN expression.
Takeaway
This study found that when a protein called PTEN is missing in colorectal cancer, it can make the cancer spread more and make it harder for patients to survive.
Methodology
Analyzed 69 pairs of primary colorectal cancer and liver metastasis specimens using immunohistochemistry.
Participant Demographics
Mean age of participants was 60.7 years, with 40 males and 29 females in the liver metastasis group.
Statistical Information
P-Value
p = 0.012
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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