Effectiveness of Tigecycline Against Acinetobacter baumannii Infections in Italy
Author Information
Author(s): Mezzatesta Maria Lina, Trovato Giusi, Gona Floriana, Nicolosi Vito Mar, Nicolosi Daria, Carattoli Alessandra, Fadda Giovanni, Nicoletti Giuseppe, Stefani Stefania
Primary Institution: Department of Microbiological and Gynaecological Sciences, University of Catania, Italy
Hypothesis
This study aimed to determine the in vitro activity of tigecycline and comparators against carbapenem-resistant and susceptible Acinetobacter baumannii strains in Italy.
Conclusion
Tigecycline showed good activity against multidrug-resistant Acinetobacter baumannii strains, maintaining a consistent MIC90 of 2 mg/L against both carbapenem-susceptible and resistant strains.
Supporting Evidence
- Over 90% of A. baumannii strains were resistant to ceftazidime, ciprofloxacin, and aztreonam.
- Tigecycline had a MIC90 of 2 mg/L against the tested strains.
- Colistin was effective against 99% of the strains, with only one resistant isolate.
- The study identified multiple resistance mechanisms, including the presence of OXA-type enzymes.
Takeaway
Tigecycline is a strong medicine that works well against a tough germ called Acinetobacter baumannii, which can make people very sick.
Methodology
The study used broth microdilution methods to test antibiotic susceptibility and PCR assays to identify resistance genes.
Limitations
The study was limited to strains collected from specific hospitals in Italy, which may not represent all geographical regions.
Participant Demographics
Strains were collected from 9 hospitals in Italy, primarily from patients with severe infections.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website