The role of selenium, vitamin C, and zinc in benign thyroid diseases and of selenium in malignant thyroid diseases: Low selenium levels are found in subacute and silent thyroiditis and in papillary and follicular carcinoma
2008

The Role of Selenium, Vitamin C, and Zinc in Thyroid Diseases

Sample size: 1401 publication Evidence: moderate

Author Information

Author(s): Roy Moncayo, Alexander Kroiss, Manfred Oberwinkler, Fatih Karakolcu, Matthias Starzinger, Klaus Kapelari, Heribert Talasz, Helga Moncayo

Primary Institution: Medical University of Innsbruck, Austria

Hypothesis

The study aims to evaluate the levels of nutritional antioxidants and their association with thyroid function and pathology.

Conclusion

Patients with benign or malignant thyroid diseases can present low selenium levels compared to controls.

Supporting Evidence

  • Low selenium levels were found in 20.3% of patients with thyroid diseases.
  • Significantly decreased selenium levels were observed in cases of sub-acute and silent thyroiditis.
  • Vitamin C and zinc levels did not correlate with thyroid disease parameters.

Takeaway

This study found that people with thyroid problems often have low levels of selenium, which is important for thyroid health.

Methodology

The study evaluated 1401 subjects, including controls and patients with benign and malignant thyroid diseases, measuring levels of selenium, vitamin C, and zinc.

Limitations

The study did not find significant associations between vitamin C or zinc levels and thyroid disease.

Participant Demographics

The study included 1186 adults and 215 children, with various thyroid conditions.

Statistical Information

P-Value

p<0.001

Statistical Significance

p<0.001

Digital Object Identifier (DOI)

10.1186/1472-6823-8-2

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