Neonatal Outcomes in Preterm Multiple Births: Impact of Conception Method
Author Information
Author(s): Shah Vibhuti, AlWassia Haydi, Shah Karan, Yoon Woojin, Shah Prakeshkumar
Primary Institution: Mount Sinai Hospital
Hypothesis
Preterm multiple births ≤ 32 weeks GA born following the use of ART will have increased rate of adverse composite outcome.
Conclusion
The mode of conception had no detectable effect on the adjusted composite neonatal outcome of mortality and/or three neonatal morbidities.
Supporting Evidence
- The unadjusted composite outcome rate was significantly higher in preterm multiples born following ART vs. SC.
- When adjusted for confounders, the difference between groups was not statistically significant.
- Mortality and incidence of chronic lung disease were significantly higher in the ART group.
Takeaway
This study looked at babies born early in multiple births and found that how they were conceived (through ART or naturally) didn't change their chances of serious health problems.
Methodology
A single center cohort study comparing outcomes of preterm multiple births ≤ 32 weeks GA born following ART vs. SC, using retrospective data collection.
Potential Biases
Potential bias due to non-blinding of clinicians to mode of conception and possible differential management.
Limitations
The study excluded singletons and lacked long-term neuro-developmental outcome data.
Participant Demographics
Mothers in the ART group were older and more likely to be primiparous compared to the SC group.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI 1.13, 3.45
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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