Leptin regulation of neuronal excitability and cognitive function
2007
Leptin's Role in Brain Function
publication
Evidence: moderate
Author Information
Author(s): Harvey Jenni
Primary Institution: Neurosciences Institute, Ninewells Hospital and Medical School, University of Dundee
Hypothesis
Leptin influences neuronal excitability and cognitive function in the brain.
Conclusion
Leptin plays a crucial role in regulating neuronal functions and cognitive processes.
Supporting Evidence
- Leptin receptors are widely expressed in the brain, indicating diverse functions beyond energy regulation.
- Leptin influences learning and memory by modulating synaptic plasticity in the hippocampus.
- Leptin has been shown to have anti-depressant properties in animal models.
Takeaway
Leptin is a hormone that helps control how our brain cells work and can affect how we think and feel.
Methodology
The review summarizes recent advances in leptin neurobiology, focusing on its effects on neuronal excitability and cognitive function.
Limitations
The exact mechanisms of how leptin reaches certain brain areas and its release from neurons are not fully understood.
Digital Object Identifier (DOI)
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