San-Huang-Xie-Xin-Tang Protects Rat Hearts from Ischemia/Reperfusion Injury
Author Information
Author(s): Liou Shu-Fen, Ke Hung-Jen, Hsu Jong-Hau, Liang Jyh-Chong, Lin Hung-Hong, Chen Ing-Jun, Yeh Jwu-Lai
Primary Institution: Kaohsiung Medical University
Hypothesis
Does San-Huang-Xie-Xin-Tang (SHXT) protect rat hearts against ischemia/reperfusion-induced myocardial apoptosis?
Conclusion
SHXT significantly reduces myocardial infarct size, arrhythmia, and mortality in rats subjected to ischemia/reperfusion.
Supporting Evidence
- SHXT reduced plasma levels of cardiac enzymes and mortality rate from 53% to 0%.
- SHXT decreased the infarct size dose-dependently.
- SHXT increased the Bcl-2/Bax ratio, indicating reduced apoptosis.
Takeaway
This study shows that a traditional Chinese medicine called SHXT can help protect rat hearts from damage caused by a lack of blood flow.
Methodology
Rats were treated with SHXT before undergoing a procedure to induce ischemia/reperfusion, and various cardiac parameters were measured.
Participant Demographics
Male Wistar rats weighing 250–300 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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