Lamin A/C and Gastric Cancer Prognosis
Author Information
Author(s): Wu Zhengrong, Wu Lirong, Weng Desheng, Xu Dazhi, Geng Jian, Zhao Fei
Primary Institution: Southern Medical University, Guangzhou, PR China
Hypothesis
Reduced expression of lamin A/C is associated with poor histological differentiation and prognosis in primary gastric carcinoma.
Conclusion
Lamin A/C is involved in the pathogenesis of gastric cancer and may serve as a valuable biomarker for assessing prognosis.
Supporting Evidence
- Lamin A/C expression was downregulated in the majority of tumors compared to normal gastric tissues.
- Negative lamin A/C expression correlated strongly with histological classification.
- Patients with lamin A/C downregulation had a poorer prognosis.
Takeaway
This study found that lower levels of a protein called lamin A/C in stomach cancer tissues mean the cancer is likely to be worse and patients may not live as long.
Methodology
The study analyzed lamin A/C expression using RT-PCR, real-time RT-PCR, western blot, and immunohistochemistry on 126 gastric cancer tissue samples.
Limitations
The study does not explore the molecular mechanisms underlying the loss of lamin A/C expression.
Participant Demographics
The study included 126 primary gastric cancer patients, consisting of 88 males and 38 females with a median age of 50 years.
Statistical Information
P-Value
p = 0.034
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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