Does Early Serum LH Predict IVF/ICSI Success?
Author Information
Author(s): Kassab Ahmed, Sabatini Luca, Lieberman Gidon, Tozer Amanda, Zosmer Ariel, Davis Colin, Al-Shawaf Talha
Primary Institution: Barts and The London Centre for Reproductive Medicine
Hypothesis
Can measuring early basal serum follicular luteinising hormone (LH) predict the outcomes of IVF/ICSI treatments?
Conclusion
Early follicular serum LH measurements do not correlate with clinical pregnancy or live birth rates in IVF/ICSI treatments.
Supporting Evidence
- The study included 1333 consecutive IVF/ICSI cycles.
- No significant correlation was found between LH levels and pregnancy outcomes.
- Younger age and lower FSH levels were associated with higher chances of live birth.
Takeaway
This study looked at whether measuring a hormone called LH before IVF could help predict if the treatment would work. It found that it doesn't really help.
Methodology
An observational study of 1333 women undergoing IVF/ICSI, measuring serum LH in the 6 months before treatment and analyzing outcomes.
Potential Biases
Potential bias in hormone measurement timing and patient selection.
Limitations
The study did not include women with hypothalamic hypogonadism or those undergoing ovum donation.
Participant Demographics
Women aged 18-45, with a median age of 34 years and a median BMI of 24.
Statistical Information
P-Value
p=0.76 for CP, p=0.9 for LB
Confidence Interval
95% CI 0.917–0.968 for age, 95% CI 0.876–0.965 for FSH
Statistical Significance
p>0.05
Digital Object Identifier (DOI)
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