No Benefit of Meropenem–Vaborbactam over Meropenem for Pseudomonas aeruginosa
Author Information
Author(s): Dinh Aurélien, Bleibtreu Alexandre, Duran Clara, Bouchand Frédérique, Bosch Alexie, Crozon-Clauzel Jullien, Roncato-Saberan Mariam, Matt Morgan, Boibieux André, Fanton Annlyse, Wille Heidi, Fiaux Elise, Pilmis Benoît, Lacoste Marie, Saint-Genis Quentin, Thumerelle Caroline, Pavese Patricia, Vuotto Fanny, Senneville Eric, Potron Anaïs, Corvec Stéphane, Boutoille David, Jeannot Katy, Dortet Laurent
Primary Institution: Infectious Disease Unit, Raymond-Poincaré University Hospital, AP-HP Paris Saclay University, France
Hypothesis
Does meropenem–vaborbactam provide any significant advantage over meropenem alone in treating Pseudomonas aeruginosa infections?
Conclusion
Meropenem–vaborbactam does not show significant benefits compared to meropenem for treating Pseudomonas aeruginosa infections.
Supporting Evidence
- Overall, 21 patients from 15 French hospitals were included in the study.
- The main indication for MEM-VAB treatment was respiratory tract infections.
- 13 out of 21 patients met the predefined criteria for clinical cure, indicating an overall cure rate of 61.9%.
- MEM-VAB demonstrated notable activity against KPC-producing Enterobacterales.
- Vaborbactam did not provide any advantage in treating Pseudomonas aeruginosa infections.
Takeaway
This study looked at a new antibiotic treatment and found that it doesn't work better than an older one for a specific infection.
Methodology
A national multicenter retrospective study was conducted, including all patients who received at least one dose of MEM-VAB between 20 July 2020, and 5 April 2022.
Potential Biases
Potential biases due to the retrospective nature of the study and the lack of information on the rationale for choosing MEM-VAB over other antibiotics.
Limitations
The study's retrospective design may lead to potential missing data and inherent biases.
Participant Demographics
Mean age was 53.2 years, with a sex ratio of 3.2; 42.9% were immunocompromised.
Digital Object Identifier (DOI)
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