Effects of a Polyphenol-Rich Beverage on Blood Biomarkers
Author Information
Author(s): Boris V Nemzer, Liliana C Rodriguez, Linda Hammond, Robert DiSilvestro, John M Hunter, Zbigniew Pietrzkowski
Primary Institution: FutureCeuticals, Inc.
Hypothesis
Does the acute intake of a polyphenol-rich beverage affect serum biomarkers related to oxidation and inflammation?
Conclusion
The polyphenol-rich beverage significantly reduced certain blood biomarkers related to oxidative stress and inflammation.
Supporting Evidence
- A single dose of the beverage reduced serum 8-iso-PGF2-alpha levels by 40%.
- The beverage also decreased advanced oxidation protein products by 39%.
- Both treatment groups showed significant increases in hydroxyl radical antioxidant capacity.
Takeaway
Drinking a special fruit and vegetable drink can help lower some bad stuff in your blood that makes you sick.
Methodology
A double-blinded, placebo-controlled pilot study with 31 healthy subjects who consumed a polyphenol-rich beverage and had their blood analyzed for various biomarkers.
Potential Biases
Potential bias due to the small sample size and the exploratory nature of the study.
Limitations
The study was small and exploratory, focusing on a specific subgroup of participants with elevated biomarkers.
Participant Demographics
Healthy males and females aged 45-55 with a BMI of 25-36.
Statistical Information
P-Value
p ≤ 0.001 for 8-iso-PGF2-alpha reduction
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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