Genetic Variants in MARCO and Tuberculosis Risk
Author Information
Author(s): Ma Mai-Juan, Wang Hai-Bing, Li Hao, Yang Jun-Hai, Yan Yan, Xie Lan-Pin, Qi Ying-Cheng, Li Jun-Lian, Chen Mei-Juan, Liu Wei, Cao Wu-Chun
Primary Institution: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, People's Republic of China
Hypothesis
Are single nucleotide polymorphisms (SNPs) in the MARCO gene associated with susceptibility to pulmonary tuberculosis in the Chinese Han population?
Conclusion
The study found that genetic variants in the MARCO gene are associated with an increased risk of pulmonary tuberculosis in the Chinese Han population.
Supporting Evidence
- The study identified 17 SNPs in the MARCO gene.
- One SNP (rs17009726) was associated with a 1.65 fold increased risk of pulmonary tuberculosis.
- Haplotype analysis revealed significant associations with two haplotypes containing the G allele of rs17009726.
Takeaway
Some people might be more likely to get tuberculosis because of their genes, especially a gene called MARCO.
Methodology
The study used a hospital-based case-control association study design, genotyping 17 tagging SNPs in 923 pulmonary tuberculosis patients and 1033 healthy controls.
Potential Biases
Potential misclassification of healthy controls due to unknown latent TB infection status.
Limitations
The study lacked independent replication in other ethnic populations and detailed patient information, which may affect the certainty of the associations.
Participant Demographics
Participants were all of Chinese Han descent, including 923 pulmonary tuberculosis patients and 1033 healthy controls.
Statistical Information
P-Value
9.27E-5
Confidence Interval
95% CI = 1.32–2.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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