Catalogues of Mammalian Long Noncoding RNAs
Author Information
Author(s): Ana C. Marques, Chris P. Ponting
Primary Institution: MRC Functional Genomics Unit, University of Oxford
Hypothesis
What is the evolutionary conservation and functionality of long noncoding RNAs in mice?
Conclusion
The study indicates that the two ncRNA catalogues unevenly and lightly sample the true, much larger, ncRNA repertoire of the mouse.
Supporting Evidence
- MacroRNAs and lincRNAs both show significant overrepresentation of conserved sequence elements.
- MacroRNA exons exhibit a higher proportion of constrained sequences compared to lincRNA exons.
- Evidence for transcription of human-aligned ncRNA exons is available for only a small percentage of both macroRNAs and lincRNAs.
Takeaway
Scientists are trying to understand how many long noncoding RNAs exist in mice and how they work, but they found that many are still undiscovered.
Methodology
The study involved comparative evolutionary analysis of two mouse long noncoding RNA libraries to assess their conservation and functionality.
Limitations
The study may not account for all long noncoding RNAs due to the incomplete nature of the catalogues.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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