Rikkunshito Improves Gastric Emptying in Rats
Author Information
Author(s): K. Tominaga, T. Kido, M. Ochi, C. Sadakane, A. Mase, H. Okazaki, H. Yamagami, T. Tanigawa, K. Watanabe, T. Watanabe, Y. Fujiwara, N. Oshitani, T. Arakawa
Primary Institution: Osaka City University Graduate School of Medicine
Hypothesis
Does rikkunshito affect gastric motility associated with 5-HT or dopamine receptors?
Conclusion
Rikkunshito and its active ingredient hesperidin improve gastric emptying delays via the 5-HT3 receptor pathway.
Supporting Evidence
- Rikkunshito significantly suppressed the delay in gastric emptying caused by 5-HT.
- Hesperidin, an active ingredient in rikkunshito, also improved gastric emptying delays.
- Atropine pretreatment blocked the effects of rikkunshito and ondansetron on gastric emptying.
Takeaway
Rikkunshito is a traditional Japanese medicine that helps food move through the stomach faster by blocking certain signals in the body.
Methodology
The study used male Wistar rats to test the effects of rikkunshito on gastric emptying delays induced by 5-HT and dopamine.
Limitations
The specific signal transduction pathways and targeted molecules after binding of the 5-HT3 receptor agonist were not elucidated.
Participant Demographics
Male Wistar rats, age 9 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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