Neurite Outgrowth Mediated by Translation Elongation Factor eEF1A1: A Target for Antiplatelet Agent Cilostazol
2011
Cilostazol and Nerve Growth Factor-Induced Neurite Outgrowth
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Kenji Hashimoto, Tamaki Ishima
Primary Institution: Chiba University, Chiba, Japan
Hypothesis
Cilostazol enhances nerve growth factor-induced neurite outgrowth through specific cellular mechanisms.
Conclusion
Cilostazol significantly increases neurite outgrowth in PC12 cells by enhancing the levels of eEF1A1 protein and interacting with various signaling pathways.
Supporting Evidence
- Cilostazol significantly increased the number of cells with neurites in a concentration-dependent manner.
- Specific inhibitors of signaling pathways blocked the potentiation of NGF-induced neurite outgrowth by cilostazol.
- eEF1A1 protein levels were significantly increased by cilostazol treatment.
Takeaway
Cilostazol helps nerve cells grow better, which could be useful for treating brain diseases.
Methodology
The study used PC12 cells to assess the effects of cilostazol on NGF-induced neurite outgrowth and analyzed the involvement of various signaling pathways.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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