Urinary IL-18 and Acute Kidney Injury After Cardiac Surgery
Author Information
Author(s): Michael Haase, Rinaldo Bellomo, David Story, Piers Davenport, Anja Haase-Fielitz
Primary Institution: Austin Health, Melbourne
Hypothesis
Urinary IL-18 measured during the immediate postoperative period would be a promising predictor of acute kidney injury following adult cardiac surgery.
Conclusion
Early postoperative measurement of urinary IL-18 does not help identify patients who develop acute kidney injury after cardiac surgery.
Supporting Evidence
- Twenty patients developed acute kidney injury.
- Urinary IL-18 was not different in patients who developed AKI compared to those who did not.
- Urinary IL-18 correlated with the duration of cardiopulmonary bypass.
Takeaway
The study looked at whether a substance called IL-18 in urine could help doctors predict kidney problems after heart surgery, but it turns out it doesn't really help.
Methodology
This was a single-centre prospective observational cohort study involving 100 adult cardiac surgical patients, measuring urinary IL-18 and creatinine at various time points.
Potential Biases
Potential confounding factors related to patient comorbidities and the single-centre design.
Limitations
The study was conducted at a single centre, and findings may not be generalizable to other settings.
Participant Demographics
Adult cardiac surgical patients, with a mean age of 75.3 years for those who developed AKI.
Statistical Information
P-Value
0.70
Confidence Interval
0.38 to 0.68
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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