LDL Cholesterol and Mortality in Hypertensive Patients
Author Information
Author(s): Liang Guoliang, Zhang Wenhao, Gu Xinxin, Zhang Qiong, Liu Ankang, Qing Xinran, Ma Jiangwei
Primary Institution: Department of Cardiovascular Medicine, Fengxian District Central Hospital, Shanghai, China
Hypothesis
This study aims to investigate the relationship between low-density lipoprotein cholesterol and cardiovascular and all-cause mortality in adults with hypertension.
Conclusion
In individuals with hypertension, LDL-C was linked to cardiovascular and all-cause mortality, showing a non-linear relationship.
Supporting Evidence
- Lower levels of LDL-C were associated with a higher risk of all-cause and cardiovascular mortality.
- The lowest LDL-C group showed a 19.6% increased risk of all-cause mortality.
- Both all-cause and cardiovascular mortality showed a non-linear association with LDL-C concentration.
Takeaway
This study found that both low and high levels of LDL cholesterol can increase the risk of death in people with high blood pressure.
Methodology
The study analyzed hypertensive participants from NHANES 1999–2018 using Cox regression and survival analysis.
Potential Biases
Potential recall bias in self-reported smoking status and medication use.
Limitations
The study is limited to a U.S. population and may not be applicable to other countries; recall bias may affect self-reported data.
Participant Demographics
49.6% male, mean age 59.4 years, predominantly White (68.2%), 85.7% with high school education or above.
Statistical Information
P-Value
0.0068
Confidence Interval
95% CI 1.051–1.361
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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