Nestin and CD133 as markers for glioma outcomes
Author Information
Author(s): Zhang Mingyu, Song Tao, Yang Liang, Chen Ruokun, Wu Lei, Yang Zhuanyi, Fang Jiasheng
Primary Institution: The Neurosurgery Department of Xiangya Hospital of Central South University
Hypothesis
The study investigates the correlation of Nestin and CD133 expression with glioma grading and their prognostic value.
Conclusion
Nestin and CD133 expression may indicate the aggressive nature of gliomas and help predict patient outcomes.
Supporting Evidence
- Nestin and CD133 expression levels were significantly higher in gliomas compared to normal brain tissues.
- Higher expression of Nestin and CD133 correlated with higher glioma grades.
- Patients with low expression of these markers had longer survival rates.
Takeaway
This study found that certain markers in brain tumors can help doctors understand how serious the tumors are and how patients might do.
Methodology
The study analyzed tissue samples from glioma patients using immunohistochemical staining to assess Nestin and CD133 expression.
Participant Demographics
85 males and 40 females, mean age 48.13 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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