The Role of Autophagy in Adenomyosis and Fertility
Author Information
Author(s): Vervier Julie, Squatrito Marlyne, Nisolle Michelle, Henry Laurie, Munaut Carine
Primary Institution: University of Liège
Hypothesis
What is the role of autophagy in the pathogenesis of adenomyosis and its implications for fertility outcomes?
Conclusion
Autophagy has a dual role in adenomyosis, influencing both cell survival and death, which complicates its impact on fertility.
Supporting Evidence
- Seventeen eligible articles were identified, including reviews and experimental studies.
- Studies showed both increased and decreased levels of autophagy in adenomyosis.
- Increased autophagy may support the survival of ectopic endometrial cells.
- Decreased autophagy could prevent cell death, leading to abnormal growth.
- Hormonal imbalances disrupt normal autophagic activity, potentially impairing fertility.
Takeaway
Adenomyosis is a condition that can make it hard for women to get pregnant, and autophagy, a process that helps cells recycle, plays a tricky role in this.
Methodology
A systematic search was conducted in Medline, Embase, and Scopus databases to identify studies on autophagy in adenomyosis.
Potential Biases
Some studies had small sample sizes, which may introduce bias.
Limitations
Few studies with heterogeneous populations limit comparative analyses.
Participant Demographics
The studies included both human samples and murine models, with varying age ranges.
Digital Object Identifier (DOI)
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