Reduced Bone Mass and Muscle Strength in Male Mice Lacking 5α-Reductase Type 1
Author Information
Author(s): Windahl Sara H., Andersson Niklas, Börjesson Anna E., Swanson Charlotte, Svensson Johan, Movérare-Skrtic Sofia, Sjögren Klara, Shao Ruijin, Lagerquist Marie K., Ohlsson Claes
Primary Institution: Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg
Hypothesis
5α-reductase type 1 mediated local conversion of testosterone to dihydrotestosterone is important for bone metabolism.
Conclusion
Male mice lacking 5α-reductase type 1 have reduced bone mass and muscle strength due to the absence of this enzyme's expression in bone and muscle.
Supporting Evidence
- Male Srd5a1−/− mice had reduced trabecular bone mineral density and cortical bone mineral content.
- Forelimb muscle grip strength was reduced in male Srd5a1−/− mice compared to wild type mice.
- Female Srd5a1−/− mice showed increased cortical bone mass due to elevated circulating androgen levels.
Takeaway
Mice without a specific enzyme that converts testosterone into a stronger hormone have weaker bones and muscles.
Methodology
The study used Srd5a1−/− mice to analyze bone mass and muscle strength through various measurements including DXA and pQCT.
Limitations
The study did not treat Srd5a1−/− mice with dihydrotestosterone to confirm their response to it.
Participant Demographics
Four-month-old male and female mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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