Recent advances in research on multistage tumorigenesis
2000
Advances in Cancer Research on Tumor Development
publication
Author Information
Author(s): Compagni A, Christofori G
Primary Institution: Research Institute of Molecular Pathology
Hypothesis
What are the molecular mechanisms that drive the transition from normal cells to malignant tumor cells?
Conclusion
Recent research has revealed important insights into the molecular processes that lead to tumor progression.
Supporting Evidence
- Tumor development involves genetic and epigenetic changes.
- Several regulatory circuits are altered during tumor progression.
- Understanding these mechanisms can help identify targets for therapy.
Takeaway
Scientists are learning how normal cells turn into cancer cells and what changes happen during this process.
Methodology
The review summarizes findings from cultured human tumor cell lines and transgenic and knock-out mouse models.
Digital Object Identifier (DOI)
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