Gut Microbes and Meniere's Disease
Author Information
Author(s): Mochizuki Fumihiro, Komori Manabu, Shimizu Jun, Sasano Yoshiyuki, Ito Yusuke, Hoffer Michael E., Miyabe Yoshishige, Koizuka Izumi
Primary Institution: St. Marianna University School of Medicine
Hypothesis
Changes in the intestinal microbiota might affect the inner ear function of patients with Meniere's disease.
Conclusion
The study found that microbial diversity in the intestine is negatively correlated with the duration of Meniere's disease.
Supporting Evidence
- Significant negative correlations were found between disease duration and alpha diversity indexes of gut microbes in patients with Meniere's disease.
- The relative abundance of Butyricicoccus ambiguous taxa was increased in patients with Meniere's disease compared to healthy donors.
- Several genera of Oscillospiraceae were more abundant in healthy donors than in patients with Meniere's disease.
Takeaway
This study looked at the gut bacteria of people with Meniere's disease and found that the types of bacteria change as the disease lasts longer.
Methodology
The study analyzed the intestinal microbiota of 10 patients with Meniere's disease and 11 healthy donors using metagenomic sequencing.
Potential Biases
Potential biases may arise from the small number of participants and the observational nature of the study.
Limitations
The study had a small sample size and was retrospective, which may limit the generalizability of the findings.
Participant Demographics
10 patients with Meniere's disease (7 males, 3 females) and 11 healthy donors (7 males, 4 females).
Statistical Information
P-Value
0.022
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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