Comparing Two Tests for Measuring S100B Levels After Meningioma Surgery
Author Information
Author(s): Einav Sharon, Itshayek Eyal, Kark Jeremy D, Ovadia Haim, Weiniger Carolyn F, Shoshan Yigal
Primary Institution: Hadassah Hebrew University Medical Center
Hypothesis
This study quantitatively compares two methods for assessing serum concentration of S100B.
Conclusion
ELISA measurements of serum S100B levels were generally higher than those from a commercial kit, especially at concentrations suggestive of brain injury.
Supporting Evidence
- ELISA measurements tended to be higher than commercial kit measurements.
- At concentrations above 0.7 μg/L, the paired measurements were consistently outside the limits of agreement.
- No sex and age-related differences in serum S100B levels were detected using the Elecsys® method.
Takeaway
Doctors compared two tests to measure a brain injury marker in patients after surgery, finding one test often showed higher results than the other.
Methodology
A prospective, observational study with 52 adult patients undergoing meningioma surgery, comparing S100B levels using ELISA and a commercial kit.
Potential Biases
Different technicians performed the tests, which may introduce variability.
Limitations
The study does not address the diagnostic accuracy of either method or provide coefficients of variation for the measurement methods.
Participant Demographics
Adult patients aged 18-80 undergoing meningioma surgery.
Statistical Information
P-Value
p = 0.643 and 0.728
Statistical Significance
p = 0.643 and 0.728
Digital Object Identifier (DOI)
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