Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis
Author Information
Author(s): C. Caruso, G. Candore, D. Cigna, S. Tripi, G. Di Gaetano, G. Migneco, G. Montalto, I. Ruggier, A. Notarbartolo
Primary Institution: Università di Palermo
Hypothesis
The study aims to compare serum levels of soluble forms of interleukin-2 receptor, CD4, and CD8 in patients with chronic active hepatitis C and healthy subjects.
Conclusion
Patients with chronic active hepatitis C have significantly higher levels of soluble IL-2R and soluble CD8 compared to healthy controls.
Supporting Evidence
- Patients with chronic type C hepatitis have significantly higher levels of sIL-2R than normal controls.
- sCD8 levels were significantly increased in patients, while no significant difference was observed for sCD4.
- No correlation was demonstrated between the levels of sIL-2R and sCD8.
Takeaway
The study found that people with chronic hepatitis C have more of certain immune proteins in their blood than healthy people, which shows their immune system is active.
Methodology
The study involved 84 subjects, including 33 patients with chronic hepatitis C and 51 healthy controls, with blood samples analyzed for soluble IL-2R, CD4, and CD8 levels.
Limitations
The study does not establish a correlation between immune activation markers and liver function parameters.
Participant Demographics
33 patients (12 females, 21 males, ages 40-65) and 51 healthy adults (26 females, 25 males, ages 20-64).
Statistical Information
P-Value
p=2.77-6 for sIL-2R and sCD8
Statistical Significance
p<0.05
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