CEACAM6 Gene Variants in Inflammatory Bowel Disease
Author Information
Author(s): Glas Jürgen, Seiderer Julia, Fries Christoph, Tillack Cornelia, Pfennig Simone, Weidinger Maria, Beigel Florian, Olszak Torsten, Lass Ulrich, Göke Burkhard, Ochsenkühn Thomas, Wolf Christiane, Lohse Peter, Müller-Myhsok Bertram, Diegelmann Julia, Czamara Darina, Brand Stephan
Primary Institution: Ludwig-Maximilians-University, Munich, Germany
Hypothesis
The study aimed to investigate the role of genetic variants in the CEACAM6 region in patients with inflammatory bowel diseases (IBD).
Conclusion
The study found no significant association of CEACAM6 variants with IBD susceptibility or ileal Crohn's disease phenotype.
Supporting Evidence
- The study included 2,683 genomic DNA samples from patients with Crohn's disease, ulcerative colitis, and healthy controls.
- Genotype analysis did not reveal significant associations of CEACAM6 SNPs with CD or UC susceptibility.
- Certain CEACAM6 SNPs modulated CEACAM6 expression in intestinal epithelial cell lines.
- No evidence of epistasis between CEACAM6 variants and main CD-associated variants was found.
Takeaway
Researchers looked at a gene called CEACAM6 to see if its variations affect inflammatory bowel disease, but they found no link.
Methodology
The study analyzed genomic DNA samples from patients with Crohn's disease, ulcerative colitis, and healthy controls for eight CEACAM6 SNPs.
Limitations
The sample size may have limited power to detect weak disease associations.
Participant Demographics
{"Crohn's_disease":{"n":858,"male_percentage":45.3,"female_percentage":54.7,"mean_age":40.2,"mean_bmi":23.1},"ulcerative_colitis":{"n":475,"male_percentage":47.9,"female_percentage":52.5,"mean_age":42.4,"mean_bmi":23.9},"controls":{"n":1350,"male_percentage":62.6,"female_percentage":37.4,"mean_age":45.8}}
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website