A specific gene expression program underlies antigen archiving by lymphatic endothelial cells in mammalian lymph nodes
2024
Gene Program for Antigen Archiving in Lymph Nodes
publication
Author Information
Author(s): Tamburini Beth, Sheridan Ryan, Doan Thu, Lucas Cormac, Forward Tadg, Fleming Ira, Uecker-Martin Aspen, Morrison Thomas, Hesselberth Jay
Hypothesis
How do lymphatic endothelial cells achieve durable antigen archiving and do they express unique transcriptional programs?
Conclusion
Lymphatic endothelial cells have a unique transcriptional program that predicts their capacity to archive antigens.
Supporting Evidence
- Lymphatic endothelial cells actively acquire and archive foreign antigens.
- A prime-boost strategy showed increased antigen levels in lymphatic endothelial cells after a second immunization.
- Machine learning was used to define a unique transcriptional program within archiving lymphatic endothelial cells.
Takeaway
Lymphatic cells in our body can remember germs for a long time, and scientists found a special way they do this.
Methodology
Single cell sequencing and spatial transcriptomics were used to study antigen levels in lymphatic endothelial cells and dendritic cells.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website