Ki-67 Expression and Recurrence in Oral Tongue Cancer
Author Information
Author(s): Wangsa D, Ryott M, Åvall-Lundqvist E, Petersson F, Elmberger G, Luo J, Ried T, Auer G, Munck-Wikland E
Primary Institution: Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden
Hypothesis
Can Ki-67 expression predict locoregional recurrence in stage I oral tongue carcinoma?
Conclusion
High Ki-67 expression is correlated with an increased risk of locoregional recurrence in stage I oral tongue squamous cell carcinoma patients.
Supporting Evidence
- 97% of cases were characterized as being aneuploid.
- High Ki-67 expression correlated with a higher number of locoregional recurrences in stage I patients.
- Preoperative radiotherapy significantly reduced proliferative activity in patients.
Takeaway
This study found that a high level of a specific protein called Ki-67 in early-stage tongue cancer can mean a higher chance of the cancer coming back after treatment.
Methodology
The study analyzed 76 pretreatment biopsy specimens and 11 surgical specimens for Ki-67 expression and genomic instability.
Potential Biases
Potential bias due to the retrospective nature of the study and the variability in treatment approaches.
Limitations
The study had a small population size and varied treatment modalities across different stages.
Participant Demographics
Patients with histopathologically confirmed oral tongue squamous cell carcinoma, stages I-IV.
Statistical Information
P-Value
0.028
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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