Breast enlargement associated with low dose olanzapine
2011
Breast Enlargement Linked to Low Dose Olanzapine
Sample size: 1
publication
Evidence: low
Author Information
Author(s): Ashish Aggarwal, Ashish Khandelwal, Manish Jain, R.C. Jiloha
Primary Institution: G.B. Pant Hospital, New Delhi, India
Hypothesis
Can low doses of olanzapine cause breast enlargement due to hyperprolactinemia?
Conclusion
Olanzapine at a low dose can lead to breast enlargement due to elevated prolactin levels.
Supporting Evidence
- Olanzapine is generally considered to have little effect on prolactin levels.
- The patient's prolactin level increased significantly after starting olanzapine.
- Breast tissue removed during surgery showed hypertrophy of glandular tissue.
- Other causes of hyperprolactinemia were ruled out through normal investigations.
Takeaway
A woman taking a low dose of olanzapine for OCD developed breast enlargement, which was linked to high prolactin levels caused by the medication.
Methodology
Case report detailing the patient's treatment and subsequent observations.
Potential Biases
Potential bias in reporting a single case without broader evidence.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
40-year-old married female with a history of OCD.
Digital Object Identifier (DOI)
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