Long-term outcomes in schizophrenia treatment
Author Information
Author(s): Cuyún Carter Gebra, Milton Denái R, Ascher-Svanum Haya, Faries Douglas E
Primary Institution: Eli Lilly and Company
Hypothesis
What baseline predictors are associated with sustained favorable long-term outcomes in patients with schizophrenia?
Conclusion
Only a small percentage of patients achieved sustained favorable long-term outcomes, indicating a need for improved treatment strategies for schizophrenia.
Supporting Evidence
- Only 10% of patients experienced sustained favorable long-term outcomes.
- Patients with better quality of life and more daily activities were more likely to achieve favorable outcomes.
- The study identified 5 distinct health state clusters among patients.
Takeaway
Most people with schizophrenia don't get better over time, but some things like having a job or feeling clearer in your thoughts can help you do better.
Methodology
The study used a hierarchical cluster analysis and stepwise logistic regression on data from a large observational study.
Potential Biases
The sample included mostly outpatients, which may not represent all patients with schizophrenia.
Limitations
The study had infrequent assessments and may not have captured all relevant changes in patients' conditions.
Participant Demographics
Participants were adults 18 years and older, treated for schizophrenia, and included a diverse population.
Statistical Information
P-Value
p = .0029
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website