How Hemerocallis citrina Baroni Helps Treat Depression
Author Information
Author(s): Gao Shan, Lu Jihui, Gu Yixiao, Zhang Yaozhi, Wang Cheng, Gao Feng, Dai Ziqi, Xu Shujing, Zhang Jindong, Yang Yuqin, Lei Haimin
Primary Institution: School of Chinese Pharmacy, Beijing University of Chinese Medicine
Hypothesis
The study aims to identify the bioactive constituents of Hemerocallis citrina Baroni and elucidate its underlying mechanism for the treatment of depression.
Conclusion
Hemerocallis citrina Baroni can alleviate depression symptoms by influencing the PI3K/Akt/CREB signaling pathway.
Supporting Evidence
- 62 chemical constituents were identified from HCB, including 13 potential active constituents targeting 49 depression-associated proteins.
- HCB significantly reduced cognitive impairment, anxiety-like behavior, and anhedonia-like behavior.
- Expression levels of 5-HT, DA, and BDNF were elevated in the hippocampal CA3 region after HCB treatment.
- Network pharmacology and transcriptomic findings suggest that the PI3K/Akt/CREB signaling pathway is critical for the therapeutic efficacy of HCB in depression.
Takeaway
This study found that a traditional herb called Hemerocallis citrina Baroni can help people feel better when they're sad by working on important brain pathways.
Methodology
The study used UHPLC-Q-Orbitrap HRMS for chemical analysis, chronic unpredictable mild stress (CUMS) for evaluating antidepressant effects, and network pharmacology combined with RNA sequencing for mechanism investigation.
Potential Biases
Potential biases may arise from the unpredictability of animal behavior and the complexity of modeling depression.
Limitations
The study's limitations include variability in animal behavior and the lack of standardized CUMS procedures.
Participant Demographics
ICR male mice, 18-22 g, 7 weeks old.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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