Radiotherapy and Survival in Transitional Cell Carcinoma
Author Information
Author(s): Chen Bing, Zeng Zhao-Chong, Wang Guo-Min, Zhang Li, Lin Zong-Ming, Sun Li-An, Zhu Tong-Yu, Wu Li-Li, Zhang Jian-Ying, Ji Yuan
Primary Institution: Zhongshan Hospital, Fudan University
Hypothesis
Does external beam radiotherapy improve overall survival and delay bladder tumor relapse in patients with T3/T4 transitional cell carcinoma of the renal pelvis or ureter?
Conclusion
EBRT may improve overall survival for patients with T3/T4 cancer of the renal pelvis or ureter and delay bladder tumor recurrence in all patients.
Supporting Evidence
- The overall survival rates for the RT and non-RT groups were not significantly different (p = 0.198).
- A significant difference was observed in the bladder tumour relapse rate between the irradiated and non-irradiated bladder groups (p = 0.004).
- The median survival period was 55.0 months for the entire cohort.
Takeaway
This study looked at patients with a specific type of kidney cancer and found that radiation treatment can help them live longer and avoid bladder cancer coming back.
Methodology
The study treated 133 patients with TCC using either external beam radiotherapy or intravesical chemotherapy and compared their outcomes.
Potential Biases
Selection bias due to non-randomized design and physician preference for treatment.
Limitations
The study was non-randomized and used various radiation techniques, which may introduce bias.
Participant Demographics
Patients aged 34 to 91 years, with a mean age of 67.8 years; included both males and females.
Statistical Information
P-Value
0.198
Confidence Interval
95% confidence interval of ± 3.14 days
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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