Effects of Sustained Inflation and Pressure Trials in Pigs with Lung Injury
Author Information
Author(s): Ralf M Muellenbach, Markus Kredel, Bernd Zollhoefer, Christian Wunder, Norbert Roewer, Joerg Brederlau
Primary Institution: Department of Anaesthesiology, University of Wuerzburg
Hypothesis
HFOV will reverse hypoxia at a lower mPaw than conventional lung protective ventilation.
Conclusion
A sustained inflation followed by an incremental mean airway pressure trial in HFOV improved oxygenation at a lower mPaw than during conventional lung protective ventilation.
Supporting Evidence
- The SI led to a significant improvement of the PaO2/FiO2-Index during HFOV compared to lung injury and PCV.
- Augmentation of mPaw improved gas exchange and pulmonary shunt fraction in both groups.
- Cardiac output was continuously deteriorating during the recruitment manoeuvre in both study groups.
Takeaway
The study tested how different breathing methods help pigs with lung injury breathe better. It found that one method worked better with less pressure.
Methodology
Eighteen healthy pigs were induced with severe lung injury and randomly assigned to two ventilation groups: pressure controlled ventilation and high-frequency oscillatory ventilation.
Limitations
The study was performed in pigs and may not represent human ARDS complexity.
Participant Demographics
Eighteen healthy female pigs, Pietrain breed, weighing 55.3 ± 3.9 kg.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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