Platelet Count and Esophageal Cancer
Author Information
Author(s): Aminian Ali, Karimian Faramarz, Mirsharifi Rasoul, Alibakhshi Abbas, Dashti Habibollah, Jahangiri Yosra, Safari Saeed, Ghaderi Hamid, Noaparast Morteza, Hasani Sharareh M., Mirsharifi Alireza
Primary Institution: Tehran University of Medical Sciences
Hypothesis
Increased platelet count may be associated with unfavorable prognosis in esophageal carcinoma.
Conclusion
Platelet count does not correlate with prognostic factors in esophageal cancer, but is significantly different between squamous cell carcinoma and adenocarcinoma.
Supporting Evidence
- 93% of cases were squamous cell carcinoma and 7% were adenocarcinoma.
- The mean platelet count was 245±76 (× 10^9 /L).
- There was a weak linear correlation between platelet count and tumor size (P= 0.03).
- Patients with adenocarcinoma had a higher platelet count than those with SCC (P= 0.003).
Takeaway
This study looked at how platelet counts relate to esophageal cancer. It found that while platelet counts don't really help predict how bad the cancer is, they are higher in patients with adenocarcinoma compared to those with squamous cell carcinoma.
Methodology
Retrospective study of 381 esophageal cancer patients who underwent esophagectomy, analyzing preoperative platelet counts and various prognostic factors.
Potential Biases
The high incidence of squamous cell carcinoma compared to adenocarcinoma may have affected statistical analysis.
Limitations
Data was collected retrospectively and thymidine phosphorylase levels were not measured.
Participant Demographics
Mean age was 62.8 years; 53% male and 47% female.
Statistical Information
P-Value
0.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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