Effects of Sida rhomboidea Leaf Extract on Obesity in Mice
Author Information
Author(s): Thounaojam Menaka C., Jadeja Ravirajsinh N., Ramani Umed V., Devkar Ranjitsinh V., Ramachandran A. V.
Primary Institution: The M. S. University of Baroda
Hypothesis
Does Sida rhomboidea leaf extract prevent obesity by modulating gene expression related to adipogenesis and leptin release in high fat diet fed mice?
Conclusion
Sida rhomboidea leaf extract significantly reduces body weight gain and adipocyte differentiation in high fat diet fed mice by down-regulating key genes involved in fat accumulation.
Supporting Evidence
- SRLE supplementation significantly prevented HFD induced increment in bodyweight.
- SRLE reduced food intake and down-regulated PPARγ2 and leptin gene expressions.
- Adipogenesis of 3T3L1 pre-adipocytes was significantly retarded in the presence of SRLE extract.
Takeaway
This study shows that a plant called Sida rhomboidea can help mice not get as fat when they eat a lot of fatty food by changing how their bodies handle fat.
Methodology
The study involved feeding male C57BL/6J mice a high fat diet with or without Sida rhomboidea leaf extract for 20 weeks and assessing body weight, plasma lipids, and gene expression in adipose tissue.
Limitations
The study was conducted on mice, and results may not directly translate to humans.
Participant Demographics
Male C57BL/6J mice, 6–8 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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