Chemotherapy and BMI Affect Fatigue in Colon Cancer Patients
Author Information
Author(s): Anneke Kastelein, Floortje Mols, Laura Kervezee, Niels H. Chavannes, Hans Gelderblom, Jacques Neefjes, Chris Hinnen
Primary Institution: Leiden University Medical Center
Hypothesis
Obese cancer patients receiving chemotherapy may experience more severe cancer-related fatigue (CRF).
Conclusion
Chemotherapy and BMI both influence long-term fatigue in colon cancer patients, indicating a need for proactive monitoring and lifestyle interventions.
Supporting Evidence
- Patients receiving chemotherapy reported more fatigue during treatment compared to those who did not.
- Obese patients reported higher fatigue levels at follow-up compared to those with a healthy BMI.
- Chemotherapy-treated patients with a BMI ≥30 reported the highest fatigue two years after treatment.
Takeaway
This study found that colon cancer patients who are obese and receive chemotherapy feel more tired for a longer time after treatment.
Methodology
Data from 333 colon cancer patients was analyzed using linear mixed-effects models to evaluate the interaction between chemotherapy and BMI on fatigue over time.
Potential Biases
Response bias may occur due to self-reported data on height and weight.
Limitations
The study did not account for chemotherapy type or dosing schedule, and self-reported height and weight may introduce bias.
Participant Demographics
The sample included 60% males, with a majority being overweight (47.7%) or obese (19.5%).
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 10.6–14.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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