Management and Outcome in Neonates with Thrombotic Events

Sample size: 32 publication Evidence: moderate

Author Information

Author(s): H. A. van Elteren, H. S. Veldt, A. B. te Pas, A. A. W. Roest, F. J. Smiers, W. J. Kollen, A. Sramek, F. J. Walther, E. Lopriore

Primary Institution: Leiden University Medical Centre

What is the incidence, management, complications, and outcome in neonates with thrombotic events?

Complete or partial clot resolution in neonatal thrombosis occurred in both the treated group and nontreated group.

Thrombotic events were identified in 32 of 4734 neonates (0.7%).
68% of treated neonates had complete resolution of the clot within 3 months.
86% of nontreated neonates had complete resolution of the clot within 2 months.
Major complications due to anticoagulant therapy occurred in 12% of treated cases.

This study looked at babies with blood clots and found that many got better whether they were treated with medicine or not.

Retrospective chart review of neonates with thrombotic events admitted to a neonatal intensive care unit from January 2004 to July 2010.

Potential bias associated with retrospective studies does not allow for comparison of outcomes between treatment and expectant management.

The study had a small number of neonates and was retrospective, which may introduce bias.

Majority were neonates with gestational age <32 weeks (63%) or very low birth weight (<1500 g) (59%).

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