Granzyme B Variants and Transplant Outcomes
Author Information
Author(s): Espinoza Luis J., Takami Akiyoshi, Nakata Katsuya, Yamada Kayoko, Onizuka Makoto, Kawase Takakazu, Sao Hiroshi, Akiyama Hideki, Miyamura Koichi, Okamoto Shinichiro, Inoue Masami, Fukuda Takahiro, Morishima Yasuo, Kodera Yoshihisa, Nakao Shinji
Primary Institution: Kanazawa University Hospital
Hypothesis
A defect of inducing apoptosis in mutant granzyme B could influence the clinical outcomes of HSCT.
Conclusion
The granzyme B genotype is associated with better clinical outcomes in patients with myeloid malignancies after unrelated bone marrow transplantation.
Supporting Evidence
- Patients with myeloid malignancies who received transplants from donors with the G/G or A/G genotype had a significantly better 5-year overall survival.
- The recipient G/G or A/G genotype was associated with a significantly better overall survival and a trend toward reduced transplant-related mortality.
- Granzyme B polymorphism did not significantly influence transplant outcomes in patients with lymphoid malignancies.
Takeaway
This study found that certain genetic variants of granzyme B can help patients with blood cancers do better after a bone marrow transplant.
Methodology
Granzyme B genotyping was performed on 613 recipients with hematological malignancies and their unrelated donors who underwent BMT through the Japan Marrow Donor Program.
Limitations
The study is limited by the number of patients evaluated and the lack of data on the causes of infections.
Participant Demographics
{"recipient_age":{"median":36,"range":"1–70"},"donor_age":{"median":34,"range":"20–57"},"recipient_sex":{"male":383,"female":230},"donor_sex":{"male":402,"female":210}}
Statistical Information
P-Value
{"overall_survival":0.01,"transplant_related_mortality":0.01}
Confidence Interval
{"overall_survival":"0.41–0.89","transplant_related_mortality":"0.25–0.80"}
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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