Tumour Vascularity and Cervix Carcinoma Prognosis
Author Information
Author(s): Cooper R A, West C M L, Wilks D P, Logue J P, Davidson S E, Roberts S A, Hunter R D
Primary Institution: Paterson Institute for Cancer Research, Christie Hospital NHS Trust
Hypothesis
The study investigates the relationship between intrinsic radiosensitivity and vascularity in cervix carcinoma treated with radiotherapy.
Conclusion
Tumour vascularity and cellular radiosensitivity are independent prognostic factors for cervix carcinoma treated with radiotherapy.
Supporting Evidence
- Patients with radioresistant and highly vascular tumours had poorer 5-year survival.
- No significant correlation was seen between IMD and SF2.
- Multivariate analysis showed that only SF2 and IMD were significant prognostic factors for survival.
Takeaway
This study found that the blood supply of a cervix cancer and how sensitive it is to radiation can help predict how well a patient will do after treatment.
Methodology
A retrospective study using immunohistochemistry to assess vascularity and previously measured intrinsic radiosensitivity in tumour biopsies.
Participant Demographics
Patients with locally advanced carcinoma of the cervix.
Statistical Information
P-Value
P = 0.0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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