Colon Cancer Risk and Hormone Replacement Therapy
Author Information
Author(s): Jürgen C. Dinger, Lothar A. J. Heinemann, Sabine Möhner, Do Minh Thai, Anita Assmann
Primary Institution: Centre for Epidemiology & Health Research Berlin
Hypothesis
What is the risk of colon cancer associated with different hormone replacement therapy (HRT) formulations?
Conclusion
Ever-use of HRT was not associated with an increased risk of colon cancer, and most risk estimates pointed toward a lower risk in HRT users.
Supporting Evidence
- The study included 354 cases of colon cancer and 1422 matched controls.
- The adjusted overall risk estimate for colon cancer associated with ever-use of HRT was 0.97.
- No substantial difference in colon cancer risk was observed between different HRT formulations.
Takeaway
This study looked at whether using hormone replacement therapy makes women more likely to get colon cancer. It found that using HRT doesn't seem to increase the risk.
Methodology
A case-control study was performed with 354 colon cancer cases and 1422 matched controls, using conditional logistic regression analysis.
Potential Biases
Potential sources of bias include differential surveillance, self-selection, recall bias, and diagnostic suspicion bias.
Limitations
Small numbers in many sub-analyses limited the ability to detect significant differences in colon cancer risk according to different hormone preparations.
Participant Demographics
Women diagnosed with colon cancer between 2000 and 2004, matched with controls based on age and residency.
Statistical Information
Confidence Interval
0.71 to 1.32
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website