Inhibition of apoptosis in human tumour cells by the tumour-associated serpin, SCC antigen-1
2000
How SCC Ag-1 Helps Cancer Cells Survive
publication
Author Information
Author(s): Suminami Y, Nagashima S, Vujanovic N L, Hirabayashi K, Kato H, Whiteside T L
Primary Institution: University of Pittsburgh Cancer Institute
Hypothesis
Does the SCC Ag-1 protein inhibit apoptosis in human tumor cells?
Conclusion
The SCC Ag-1 protein helps cancer cells survive by preventing them from undergoing programmed cell death.
Supporting Evidence
- SCC Ag-1 inhibits apoptosis induced by various agents in tumor cells.
- Inhibition of SCC Ag-1 increases sensitivity to apoptosis.
- Tumor cells with SCC Ag-1 form larger tumors in mice.
Takeaway
Cancer cells have a special protein called SCC Ag-1 that helps them live longer by stopping them from dying when they should.
Methodology
The study involved transducing tumor cells with SCC Ag-1 cDNA and assessing their apoptosis resistance in vitro and in vivo.
Digital Object Identifier (DOI)
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