Outcomes of Patent Ductus Arteriosus Ligation in Premature Infants
Author Information
Author(s): Leona C Lee, Angela Tillett, Robert Tulloh, Robert Yates, Wilf Kelsall
Primary Institution: NICU, Southmead Hospital, Bristol, UK
Hypothesis
Does the use of prostaglandin synthetase inhibitors prior to ligation affect outcomes in premature infants undergoing patent ductus arteriosus ligation?
Conclusion
Patent ductus arteriosus ligation is relatively safe, but there is significant late mortality and high morbidity among survivors.
Supporting Evidence
- Cumulative mortality rates were 2% at 7 days, 8% at 30 days, and 20% at hospital discharge.
- 77% of infants developed chronic lung disease post-surgery.
- There was no significant difference in mortality between those who received PSI and those who did not.
Takeaway
This study looked at babies who had surgery to fix a heart problem called patent ductus arteriosus. It found that while most babies survive the surgery, many still have health problems later.
Methodology
A retrospective case note review study was conducted across three hospitals to assess outcomes following PDA ligation.
Potential Biases
Potential bias due to missing follow-up data and lack of control groups.
Limitations
The study had incomplete follow-up data and was retrospective, which may affect the reliability of the results.
Participant Demographics
Infants undergoing PDA ligation from three hospitals in the UK, with no significant differences in birth gestation or weight across centers.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI for various parameters reported
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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