Vaccine Monitoring for Peste des Petits Ruminants in Ethiopia
Author Information
Author(s): Mandefro Mesafint, Ibrahim Saddam Mohammed, Sibhatu Demeke, Kassa Nebiyou, Emiyu Kemal, Debebe Kebede, Dessalegn Bereket, Birhan Mastewal, Bitew Molalegne
Primary Institution: College of Veterinary Medicine and Animal Sciences, University of Gondar, Gondar, Ethiopia
Hypothesis
What is the seroconversion rate in PPR vaccinated flocks of sheep and the seroprevalence of PPRV in unvaccinated flocks of sheep and goats?
Conclusion
The study found a suboptimal post-vaccination seroconversion rate of 76.66% in sheep, indicating a need to reevaluate the vaccination strategy.
Supporting Evidence
- The post-vaccination herd immunity was found to be 76.66%, which is below the recommended threshold of 80%.
- Seroprevalence of PPRV in unvaccinated sheep and goats was 3.61%, indicating possible circulation of the virus.
- Statistically significant differences in seroconversion rates were observed across different kebele divisions.
Takeaway
The study checked how well a vaccine worked in sheep and found that not enough sheep were protected, so they need to change how they vaccinate.
Methodology
A cross-sectional study was conducted with multistage cluster sampling to collect blood samples from vaccinated and unvaccinated small ruminants.
Limitations
The baseline serum status of vaccinated sheep was not documented due to the rapid turnover of small ruminants.
Participant Demographics
660 sheep and goats of mixed sex, aged above 6 months.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 71.46–81.34
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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