Using Sentinel Lymph Node Biopsy to Guide Surgery in Young Women with Early Cervical Cancer
Author Information
Author(s): Du Xue-lian, Sheng Xiu-gui, Jiang Tao, Li Qing-shui, Yu Hao, Pan Chun-xia, Lu Chun-hua, Wang Cong, Song Qu-qing
Primary Institution: Shandong Cancer Hospital
Hypothesis
If the SLN concept is valid in cervical cancer, most patients could avoid pelvic lymphadenectomy when the absence of metastasis is intraoperatively confirmed in the SLN.
Conclusion
The identification of SLN using 99mTc-labeled phytate is accurate and safe to assess pelvic nodes status in patients with early cervical cancer.
Supporting Evidence
- SLNs were identified in 64 of 68 patients (94.1%).
- The sensitivity, accuracy, and false negative rates were 100%, 100%, and 0%, respectively.
- All 60 patients with negative SLN underwent RAT successfully.
- Two relapses occurred and no one died of tumor progression during follow-up.
- Five of the 15 patients with procreative desire conceived 8 pregnancies after surgery.
Takeaway
Doctors can use a special test to find lymph nodes in young women with early cervical cancer, helping them keep their ability to have babies.
Methodology
68 women with stage IA2-IB1 cervical cancer underwent SLN detection using 99mTc phytate before radical abdominal trachelectomy.
Potential Biases
Potential bias in patient selection and reporting of outcomes.
Limitations
The study was limited to a specific patient population and may not be generalizable to all cervical cancer patients.
Participant Demographics
Mean age was 28 years, with a range from 18 to 41 years.
Statistical Information
P-Value
0.004
Confidence Interval
95% CI for sensitivity and accuracy was 71-100 and 89-100, respectively.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website