Effects of Anabolic Steroids on Sepsis Response
Author Information
Author(s): K. Mealy, A. Clooney, P. Marks, T. Hennessy, J. Jackson
Primary Institution: Trinity College and St James's Hospital, Dublin, Ireland
Hypothesis
Anabolic steroids might increase hepatic acute phase protein synthesis in response to sepsis.
Conclusion
Danazol increases plasma acute phase proteins in a rat model of intra-abdominal sepsis.
Supporting Evidence
- Danazol increased the a1, a2, and b1 globulin serum protein fractions compared to control groups.
- Testosterone showed less impressive trends in increasing acute phase proteins.
- All CLP groups showed a significant fall in total protein values compared to no surgery or sham groups.
Takeaway
The study found that a drug called danazol helps the body produce more proteins that fight infections when sick.
Methodology
Male Wistar rats were treated with testosterone or danazol before undergoing surgery to induce sepsis, and blood samples were analyzed for protein levels.
Limitations
The study was conducted on rats, which may not fully represent human responses.
Participant Demographics
Male Wistar rats were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Want to read the original?
Access the complete publication on the publisher's website