Impact of ThinPrep Imaging System on Pap Test Results
Author Information
Author(s): Michael J Thrall, Donna K Russell, Thomas A Bonfiglio, Rana S Hoda
Primary Institution: University of Rochester Medical Center
Hypothesis
Does the use of the ThinPrep® Imaging System alter the frequency of interpreting Papanicolaou tests as atypical squamous cells of undetermined significance?
Conclusion
The ThinPrep® Imaging System did not significantly change the rates of atypical squamous cells of undetermined significance in our laboratory.
Supporting Evidence
- Automated screening was performed on 23,103 TPPT, with 977 interpreted as ASC-US.
- Manual screening was performed on 45,789 TPPT, with 1924 interpreted as ASC-US.
- The HR-HPV positive rates were similar between TIS and MS groups.
Takeaway
Using the ThinPrep Imaging System for Pap tests doesn't change how often doctors find uncertain results, which means it can help speed up testing without causing more referrals.
Methodology
A computerized search for ASC-US cases with reflex HPV testing was conducted over a one-year period, comparing results from automated and manual screening.
Potential Biases
Selection bias may have occurred due to the random selection of cases for manual screening.
Limitations
The study was limited to a single institution and may not be generalizable to other settings.
Participant Demographics
The study included 2,716 women aged 15-85 years, with a mean age of 34 years.
Statistical Information
P-Value
0.888
Statistical Significance
p = 0.888
Digital Object Identifier (DOI)
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