Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells

1999

Cyclin D1 Protein in Ovarian Cancer

Sample size: 81 publication Evidence: moderate

Author Information

Author(s): Dhar K K, Branigan K, Parkes J, Howells R E J, Hand P, Musgrove C, Strange R C, Fryer A A, Redman C W E, Hoban P R

Primary Institution: Centre for Cell and Molecular Medicine, University of Keele School of Postgraduate Medicine, North Staffordshire Hospital, Stoke-on-Trent, UK

Hypothesis

Does the expression and localization of cyclin D1 protein correlate with tumor characteristics in epithelial ovarian cancer?

Conclusion

Cyclin D1 is frequently overexpressed in ovarian cancer, with its localization varying between cytoplasm and nucleus, but this does not correlate with tumor stage or clinical outcomes.

Supporting Evidence

Overexpression of cyclin D1 was observed in 89% of the cases examined.
Cyclin D1 was detected in both the nucleus and cytoplasm in 30% of tumors.
59% of tumors showed cyclin D1 localized exclusively in the cytoplasm.
Overexpression occurred in both borderline and invasive tumors.
There was no association between cyclin D1 overexpression and tumor stage or differentiation.
In tumors overexpressing cyclin D1, cytoplasmic localization was more common in serous histology.

Takeaway

This study looked at a protein called cyclin D1 in ovarian cancer cells and found that most tumors had too much of it, but it didn't help predict how the cancer would behave.