Cancers associated with Kaposi's sarcoma (KS) in AIDS: a link between KS herpesvirus and immunoblastic lymphoma
2001
Link Between Kaposi's Sarcoma and Immunoblastic Lymphoma in AIDS
Sample size: 189159
publication
Evidence: moderate
Author Information
Author(s): Engels E A, Rosenberg P S, Frisch M, Goedert J J
Primary Institution: National Cancer Institute
Hypothesis
Does Kaposi's sarcoma herpesvirus (KSHV) cause other malignancies in persons with AIDS?
Conclusion
Immunoblastic lymphoma is significantly associated with Kaposi's sarcoma among examined malignancies.
Supporting Evidence
- Immunoblastic lymphoma was significantly associated with Kaposi's sarcoma.
- The relative risk for immunoblastic lymphoma was adjusted for various factors.
- Only one case of immunoblastic lymphoma had pleura as the primary site.
Takeaway
This study found that people with Kaposi's sarcoma are more likely to develop a type of lymphoma, but not other cancers.
Methodology
The study used linked AIDS and cancer registries to measure cancer incidence and calculated relative risks using Poisson regression.
Participant Demographics
Included 189,159 subjects, with 26,972 having Kaposi's sarcoma.
Statistical Information
Confidence Interval
95%CI 1.29–1.93
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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