Chloroquine-resistant malaria in Ethiopia
Author Information
Author(s): Teka Hiwot, Petros Beyene, Yamuah Lawrence, Tesfaye Gezahegn, Elhassan Ibrahim, Muchohi Simon, Kokwaro Gilbert, Aseffa Abraham, Engers Howard
Primary Institution: Addis Ababa University
Hypothesis
Is chloroquine resistance present in Plasmodium vivax malaria in Debre Zeit, Ethiopia?
Conclusion
Chloroquine-resistant P. vivax parasites are emerging in Debre Zeit, Ethiopia.
Supporting Evidence
- 39.8% of participants had documented fever at enrollment.
- 4.6% of treatment failure was observed during the follow-up period.
- Blood concentrations of chloroquine were above the minimal effective concentration in patients with recurrent parasitaemia.
Takeaway
Some malaria in Ethiopia is becoming resistant to the medicine chloroquine, which means it might not work as well anymore.
Methodology
An in vivo drug efficacy study was conducted with 87 patients treated with chloroquine and followed for 28 days.
Limitations
The study did not explore other marker genes for genotyping P. vivax isolates.
Participant Demographics
Participants aged between 8 months and 52 years, with a median age of 16 years.
Statistical Information
P-Value
0.061
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website