Choroidal Response to Bevacizumab Injections in Macular Neovascularization from Central Serous Chorioretinopathy
Author Information
Author(s): David Rabinovitch, Shiri Shulman, Dafna Goldenberg, Liang Wang, Prashanth Iyer, Anat Loewenstein, Noah Igra, Olivia Levine, Gissel Herrera, Omer Trivizki
Primary Institution: Tel Aviv Medical Center, Department of Ophthalmology, Tel Aviv University, Tel Aviv, Israel
Hypothesis
What is the impact of intravitreal bevacizumab therapy on anatomical and visual outcomes in patients with macular neovascularization secondary to chronic central serous chorioretinopathy?
Conclusion
Intravitreal bevacizumab therapy significantly reduced subretinal fluid in patients with chronic central serous chorioretinopathy and secondary macular neovascularization, but did not improve visual acuity or significantly change choroidal thickness.
Supporting Evidence
- 22 eyes of 22 patients were included in the study.
- Subretinal fluid significantly decreased from baseline to final follow-up.
- 40.9% of patients achieved complete resolution of subretinal fluid.
- No significant changes were observed in best-corrected visual acuity or subfoveal choroidal thickness.
Takeaway
The study shows that a treatment called bevacizumab can help reduce fluid in the eyes of older people with a specific eye problem, but it doesn't make their vision better.
Methodology
This was a retrospective observational study reviewing medical records of treatment-naïve patients diagnosed with chronic central serous chorioretinopathy complicated by macular neovascularization treated with intravitreal bevacizumab injections over a 5-year period.
Potential Biases
The absence of a control group and reliance on retrospective data may introduce biases in treatment evaluation.
Limitations
The study's retrospective design and small sample size limit the ability to conclusively evaluate treatment efficacy and may introduce biases.
Participant Demographics
Mean age of participants was 68 years, with 82% male and 18% female.
Statistical Information
P-Value
p = 0.003
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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