Using Triglycerides to Apolipoprotein A1 Ratio to Identify Fatty Liver Disease in Diabetes
Author Information
Author(s): Wang Wei, Chen Yang, Tu Mei, Chen Hang Ju
Primary Institution: National Metabolic Management Center, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, China
Hypothesis
This study aims to evaluate the correlation between TG/APOA1 and MAFLD, as well as compare the efficacy of TG/APOA1 with other insulin resistance indexes in identifying MAFLD among individuals with T2DM.
Conclusion
TG/APOA1 serves as an effective index of insulin resistance in identifying MAFLD, offering advantages in the screening of MAFLD in T2DM.
Supporting Evidence
- TG/APOA1 was significantly higher in the MAFLD group compared to non-MAFLD.
- TG/APOA1 showed significant associations with liver fibrosis scores.
- TG/APOA1 outperformed TG/HDL-c and TyG index in identifying MAFLD.
Takeaway
This study found that a specific ratio of triglycerides to a protein called apolipoprotein A1 can help doctors find liver problems in people with diabetes.
Methodology
This cross-sectional study recruited individuals with T2DM and used abdominal CT scans to measure liver fat, comparing TG/APOA1 with other insulin resistance indexes.
Limitations
The study used CT scans instead of liver biopsies for diagnosis and was cross-sectional, limiting the ability to establish causation.
Participant Demographics
The mean age of participants was 53.5 years, with 52.8% being men.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% CI: 1.840-2.380
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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