Antiplasmodial Activity of Compounds from Ambrosia tenuifolia
Author Information
Author(s): Sülsen V., Gutierrez Yappu D., Laurella L., Anesini C., Gimenez Turba A., Martino V.
Primary Institution: Cátedra de Farmacognosia, IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, UBA
Hypothesis
The study evaluates the antiplasmodial activity of sesquiterpene lactones from Ambrosia tenuifolia against Plasmodium falciparum.
Conclusion
The compounds psilostachyin and peruvin showed significant antiplasmodial activity, particularly against the chloroquine-sensitive strain of P. falciparum.
Supporting Evidence
- The organic extract of Ambrosia tenuifolia showed a growth inhibition of 77.1% against P. falciparum.
- Peruvin was the most active compound with an IC50 value of 0.3 μg/mL against the F32 strain.
- Psilostachyin showed activity against both F32 and W2 strains with IC50 values of 0.6 and 1.8 μg/mL, respectively.
Takeaway
Researchers found that certain compounds from a plant called Ambrosia tenuifolia can help fight malaria by stopping the malaria parasite from growing.
Methodology
The study involved extracting compounds from the plant and testing their effects on malaria parasites in vitro.
Digital Object Identifier (DOI)
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